Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression
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منابع مشابه
Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression.
Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its inactivation. Therefore, 15-PGDH induction may offer a strategy to treat cancers that are driven by PGE2, such as human cholangiocarcinoma. Here, we report that omega-3 polyunsaturated...
متن کاملω-3 Polyunsaturated Fatty Acids Up-regulate the Expression of 15-PGDH by Inhibiting miR-26a and miR-26b in Human Cholangiocarcinoma Cells
Running Title: ω-3 PUFAs up-regulate the expression of 15-PGDH in cholangiocarcinoma Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Yao et al ω-3 PUFAs up-regulate the expression of 15-PGDH by inhibiting miR-26a/b ABSTRACT Prostaglandins E 2 (PGE 2) is a pro-inflammatory and pro-tumorigenic lipid mediator that promotes cholangiocarcinoma gr...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2015
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-2561